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Clinical

ER+, adjuvant tamoxifen, early stage

Purpose

This external validation set was kindly provided by the Guy's Hospital, London, United Kingdom, consisting of 77 patients diagnosed with early stage breast cancer and treated with adjuvant tamoxifen monotherapy. Samples were hybridized using Affymetrix U133PLUS2 Genechips™ according to standard Affymetrix protocols. Gene expression values from the CEL were normalized by use of the standard quantile normalization method in RMA.

Hypothesis

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen.

Experimental Design

ER+ , adjuvant tamoxifen monotherapy , early stage breast cancer

Experimental Variables

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Controls

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Methods

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Additional Information

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Microarray
Affymetrix HG-U133_Plus_2
77 Samples Loaded: 77
Human (Homo sapiens)
Breast Cancer Tissue , Guys Hospital, London, UK , Nagalla 2013
ER+ Breast Cancer
Sample Set Spreadsheet
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Samples Preview
Sample ID series IMS IBS IDS ICR
GSM232194 GUYT2 Her2 IBD WID ICR3
GSM232195 GUYT2 LumA IBD WID ICR2
GSM232196 GUYT2 NA IBE NA ICR1
GSM232197 GUYT2 LumA IBD WID ICR2
GSM232198 GUYT2 LumB IBE PID ICR3
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File
GSE9195_appended.meta.data_v1.csv
Sample Set Spreadsheet
Log2 Transformed
Raw Signal
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Sample ID Series IMS IBS IDS ICR Array Sample ID Sample Title DMFS 10Y EVENT DMFS 10Y TIME Disease Free Survival Event Distant Met Free Survival Event Age At Initial Pathologic Diagnosis Lymph Node Status ER Status PR Status Histology Differentiation Grade Tumor Size Cm Pathology T Stage Disease Free Survival Days Distant Met Free Survival Days Type Treatment
GSM232194
GUYT2
Her2
IBD
WID
ICR3
400002990
GUYT2_50261
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
64
LN+
ER+
PR-
NA
4.2
T2
3850
3850
tamoxifen
GSM232195
GUYT2
LumA
IBD
WID
ICR2
400002991
GUYT2_50262
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
73
LN+
ER+
PR+
G1
3
T2
3959
3959
tamoxifen
GSM232196
GUYT2
NA
IBE
NA
ICR1
400002992
GUYT2_50263
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
66
LN-
ER+
PR+
G1
1.83
T1c
3936
3936
tamoxifen
GSM232197
GUYT2
LumA
IBD
WID
ICR2
400002993
GUYT2_50264
DistantMetastasisFree
9.89
DiseaseFree
DistantMetastasisFree
66
LN-
ER+
PR-
G3
1.7
T1c
3610
3610
tamoxifen
GSM232198
GUYT2
LumB
IBE
PID
ICR3
400002994
GUYT2_50265
DistantMetastasis
5.73
Recurred/Progressed
DistantMetastasis
75
LN+
ER+
PR+
G3
2.1
T2
2090
2090
tamoxifen
GSM232199
GUYT2
Basal
IBE
FID
ICR4
400002995
GUYT2_50266
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
73
LN-
ER+
PR-
G3
1.6
T1c
4100
4100
tamoxifen
GSM232200
GUYT2
Her2
IBD
WID
ICR4
400002996
GUYT2_50267
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
63
LN+
ER+
PR-
G3
2.1
T2
3992
3992
tamoxifen
GSM232201
GUYT2
LumB
IBE
PID
ICR2
400002997
GUYT2_50269
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
71
LN+
ER+
PR+
G3
3.1
T2
4040
4040
tamoxifen
GSM232202
GUYT2
LumA
IBD
PID
ICR1
400002998
GUYT2_50270
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
72
LN+
ER+
PR+
G1
1.7
T1c
3679
3679
tamoxifen
GSM232203
GUYT2
LumB
IBD
PID
ICR1
400002999
GUYT2_50271
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
72
LN+
ER+
PR+
G2
2.28
T2
4124
4124
tamoxifen
GSM232204
GUYT2
Her2
IBD
PID
ICR2
400003000
GUYT2_50273
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
82
LN-
ER+
PR-
NA
1.5
T1c
3847
3847
tamoxifen
GSM232205
GUYT2
LumA
IBD
WID
ICR2
400003001
GUYT2_50282
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
62
LN+
ER+
PR+
NA
1.8
T1c
3885
3885
tamoxifen
GSM232206
GUYT2
LumA
IBD
FID
ICR3
400003002
GUYT2_50284
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
58
LN-
ER+
PR-
G2
2.3
T2
3712
3712
tamoxifen
GSM232207
GUYT2
Normal
IBE
NA
ICR4
400003003
GUYT2_50287
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
60
LN-
ER+
PR+
G3
2.5
T2
3651
3651
tamoxifen
GSM232208
GUYT2
LumA
IBD
WID
ICR2
400003004
GUYT2_50290
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
49
LN+
ER+
PR+
G1
1.57
T1c
3867
3867
tamoxifen
GSM232209
GUYT2
Normal
IBE
NA
ICR3
400003005
GUYT2_50291
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
59
LN-
ER+
PR+
G1
1.38
T1c
3839
3839
tamoxifen
GSM232210
GUYT2
Basal
IBE
WID
ICR3
400003006
GUYT2_50293
DistantMetastasisFree
8.56
DiseaseFree
DistantMetastasisFree
51
LN-
ER+
PR+
G3
2.3
T2
3124
3124
tamoxifen
GSM232211
GUYT2
LumA
IBD
PID
ICR3
400003007
GUYT2_50294
DistantMetastasis
6.62
Recurred/Progressed
DistantMetastasis
55
LN+
ER+
PR+
G2
2.9
T2
2417
2417
tamoxifen
GSM232212
GUYT2
Basal
IBE
WID
ICR3
400003008
GUYT2_50296
DistantMetastasisFree
9.12
DiseaseFree
DistantMetastasisFree
76
LN-
ER+
PR+
G3
3
T2
3329
3329
tamoxifen
GSM232213
GUYT2
Normal
IBE
NA
ICR1
400003009
GUYT2_50298
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
49
LN-
ER+
PR+
G1
1.08
T1c
3664
3664
tamoxifen
GSM232214
GUYT2
LumB
IBD
PID
ICR3
400003010
GUYT2_50299
DistantMetastasisFree
7.23
DiseaseFree
DistantMetastasisFree
69
LN-
ER+
PR+
G2
2.6
T2
2639
2639
tamoxifen
GSM232215
GUYT2
Her2
IBD
WID
ICR3
400003011
GUYT2_50300
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
74
LN-
ER+
PR-
NA
2.5
T2
3720
3720
tamoxifen
GSM232216
GUYT2
Normal
IBE
NA
ICR4
400003012
GUYT2_50301
DistantMetastasisFree
9.01
DiseaseFree
DistantMetastasisFree
42
LN-
ER+
PR+
G2
1.97
T1c
3287
3287
tamoxifen
GSM232217
GUYT2
Her2
IBE
PID
ICR2
400003013
GUYT2_50302
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
62
LN-
ER+
PR-
G3
1.8
T1c
3693
3693
tamoxifen
GSM232218
GUYT2
Normal
IBE
NA
ICR2
400003014
GUYT2_50305
DistantMetastasisFree
9.47
DiseaseFree
DistantMetastasisFree
51
LN+
ER+
PR+
G1
2.6
T2
3456
3456
tamoxifen
GSM232219
GUYT2
LumA
IBD
PID
ICR2
400003015
GUYT2_50307
DistantMetastasisFree
8.2
DiseaseFree
DistantMetastasisFree
52
LN+
ER+
PR+
G2
2
T1c
2994
2994
tamoxifen
GSM232220
GUYT2
LumB
IBE
WID
ICR4
400003016
GUYT2_50308
DistantMetastasisFree
8.43
DiseaseFree
DistantMetastasisFree
59
LN-
ER+
PR+
G3
2.25
T2
3077
3077
tamoxifen
GSM232221
GUYT2
LumB
IBE
PID
ICR1
400003017
GUYT2_50313
DistantMetastasis
7.39
Recurred/Progressed
DistantMetastasis
58
LN+
ER+
PR-
G3
6
T3/T4
1615
2696
tamoxifen
GSM232222
GUYT2
Her2
IBD
FID
ICR3
400003018
GUYT2_50316
DistantMetastasis
3.66
Recurred/Progressed
DistantMetastasis
65
LN+
ER+
PR-
G3
2.1
T2
1276
1337
tamoxifen
GSM232223
GUYT2
Her2
IBD
FID
ICR3
400003019
GUYT2_50317
DistantMetastasisFree
10
DiseaseFree
DistantMetastasisFree
50
LN+
ER+
PR+
G2
2.85
T2
3900
3900
tamoxifen
GSM232224
GUYT2
Basal
IBE
FID
ICR3
400003020
GUYT2_50318
DistantMetastasisFree
9.12
Recurred/Progressed
DistantMetastasisFree
60
LN+
ER+
PR+
G3
2
T1c
210
3330
tamoxifen
GSM232225
GUYT2
LumB
IBE
PID
ICR1
400003021
GUYT2_50319
DistantMetastasisFree
9.64
DiseaseFree
DistantMetastasisFree
68
LN-
ER+
PR+
G3
2.2
T2
3518
3518
tamoxifen
GSM232226
GUYT2
Normal
IBE
NA
ICR2
400003022
GUYT2_50320
DistantMetastasisFree
8.41
DiseaseFree
DistantMetastasisFree
59
LN-
ER+
PR-
NA
2.4
T2
3068
3068
tamoxifen
GSM232227
GUYT2
Her2
IBE
FID
ICR4
400003023
GUYT2_50321
DistantMetastasisFree
8.92
DiseaseFree
DistantMetastasisFree
61
LN-
ER+
PR+
G3
3
T2
3257
3257
tamoxifen
GSM232228
GUYT2
Her2
IBE
PID
ICR3
400003024
GUYT2_50322
DistantMetastasisFree
6.87
DiseaseFree
DistantMetastasisFree
68
LN+
ER+
PR+
G3
2.85
T2
2507
2507
tamoxifen
GSM232229
GUYT2
LumB
IBD
PID
ICR3
400003025
GUYT2_50326
DistantMetastasisFree
9.27
DiseaseFree
DistantMetastasisFree
64
LN-
ER+
PR-
NA
2.1
T2
3383
3383
tamoxifen
GSM232230
GUYT2
LumA
IBD
PID
ICR2
400003026
GUYT2_50327
DistantMetastasisFree
8.47
DiseaseFree
DistantMetastasisFree
75
LN+
ER+
PR-
G1
2.8
T2
3091
3091
tamoxifen
GSM232231
GUYT2
LumB
IBD
FID
ICR4
400003027
GUYT2_50328
DistantMetastasis
2.11
Recurred/Progressed
DistantMetastasis
77
LN+
ER+
PR+
NA
4
T2
758
771
tamoxifen
GSM232232
GUYT2
Normal
IBE
NA
ICR2
400003028
GUYT2_50330
DistantMetastasisFree
7.85
DiseaseFree
DistantMetastasisFree
52
LN-
ER+
PR+
NA
1.9
T1c
2865
2865
tamoxifen
GSM232233
GUYT2
Normal
IBE
NA
ICR2
400003029
GUYT2_50333
DistantMetastasisFree
9.16
DiseaseFree
DistantMetastasisFree
74
LN-
ER+
PR+
NA
2
T1c
3345
3345
tamoxifen
GSM232234
GUYT2
Normal
IBE
NA
ICR1
400003030
GUYT2_50335
DistantMetastasisFree
7.75
DiseaseFree
DistantMetastasisFree
60
LN-
ER+
PR+
G2
1.3
T1c
2829
2829
tamoxifen
GSM232235
GUYT2
LumA
IBD
PID
ICR1
400003031
GUYT2_50336
DistantMetastasisFree
8.33
DiseaseFree
DistantMetastasisFree
63
LN+
ER+
PR+
NA
5
T2
3040
3040
tamoxifen
GSM232236
GUYT2
Her2
IBE
PID
ICR1
400003032
GUYT2_50337
DistantMetastasis
1.28
Recurred/Progressed
DistantMetastasis
70
LN-
ER+
PR-
G3
4
T2
468
468
tamoxifen
GSM232237
GUYT2
Normal
IBE
NA
ICR1
400003033
GUYT2_50338
DistantMetastasisFree
8.53
DiseaseFree
DistantMetastasisFree
47
LN-
ER+
PR+
NA
1.6
T1c
3113
3113
tamoxifen
GSM232238
GUYT2
LumA
IBD
WID
ICR3
400003034
GUYT2_50339
DistantMetastasisFree
7.61
Recurred/Progressed
DistantMetastasisFree
75
LN-
ER+
PR+
G2
3
T2
2779
2779
tamoxifen
GSM232239
GUYT2
LumA
IBD
WID
ICR2
400003035
GUYT2_50341
DistantMetastasisFree
8.85
DiseaseFree
DistantMetastasisFree
69
LN-
ER+
PR+
G2
1.8
T1c
3232
3232
tamoxifen
GSM232240
GUYT2
Basal
IBE
PID
ICR2
400003036
GUYT2_50344
DistantMetastasisFree
8.96
DiseaseFree
DistantMetastasisFree
58
LN+
ER+
PR-
G3
2.1
T2
3270
3270
tamoxifen
GSM232241
GUYT2
LumA
IBD
PID
ICR1
400003037
GUYT2_50345
DistantMetastasisFree
7.23
DiseaseFree
DistantMetastasisFree
75
LN-
ER+
PR+
G2
4
T2
2639
2639
tamoxifen
GSM232242
GUYT2
Normal
IBE
NA
ICR3
400003038
GUYT2_50349
DistantMetastasisFree
8.3
DiseaseFree
DistantMetastasisFree
56
LN-
ER+
PR+
G2
2
T1c
3029
3029
tamoxifen
GSM232243
GUYT2
Normal
IBE
NA
ICR2
400003039
GUYT2_50353
DistantMetastasisFree
5.43
DiseaseFree
DistantMetastasisFree
77
LN-
ER+
PR+
NA
5
T2
1982
1982
tamoxifen
GSM232244
GUYT2
LumB
IBE
WID
ICR3
400003040
GUYT2_50354
DistantMetastasisFree
8.41
DiseaseFree
DistantMetastasisFree
59
LN-
ER+
PR+
G3
1.6
T1c
3068
3068
tamoxifen
GSM232245
GUYT2
NA
IBE
NA
ICR1
400003041
GUYT2_50356
DistantMetastasisFree
8.19
DiseaseFree
DistantMetastasisFree
65
LN-
ER+
PR-
G3
2.3
T2
2991
2991
tamoxifen
GSM232246
GUYT2
Her2
IBE
PID
ICR1
400003042
GUYT2_50357
DistantMetastasisFree
8.3
DiseaseFree
DistantMetastasisFree
67
LN+
ER+
PR+
NA
1.9
T1c
3028
3028
tamoxifen
GSM232247
GUYT2
Normal
IBE
NA
ICR2
400003043
GUYT2_50361
DistantMetastasisFree
7.63
DiseaseFree
DistantMetastasisFree
65
LN-
ER+
PR+
G1
1.8
T1c
2785
2785
tamoxifen
GSM232248
GUYT2
Basal
IBE
FID
ICR4
400003044
GUYT2_50362
DistantMetastasisFree
8.07
DiseaseFree
DistantMetastasisFree
50
LN-
ER+
PR+
G2
1.2
T1c
2946
2946
tamoxifen
GSM232249
GUYT2
Normal
IBE
NA
ICR1
400003045
GUYT2_50366
DistantMetastasisFree
7.12
DiseaseFree
DistantMetastasisFree
73
LN+
ER+
PR+
NA
2
T1c
2599
2599
tamoxifen
GSM232250
GUYT2
LumA
IBD
PID
ICR1
400003046
GUYT2_50368
DistantMetastasisFree
7.41
DiseaseFree
DistantMetastasisFree
70
LN+
ER+
PR+
G3
2.8
T2
2704
2704
tamoxifen
GSM232251
GUYT2
Normal
IBE
NA
ICR1
400003047
GUYT2_50369
DistantMetastasisFree
7.1
DiseaseFree
DistantMetastasisFree
52
LN-
ER+
PR+
NA
1.07
T1c
2593
2593
tamoxifen
GSM232252
GUYT2
Her2
IBD
WID
ICR3
400003048
GUYT2_50373
DistantMetastasisFree
3.08
Recurred/Progressed
DistantMetastasisFree
80
LN+
ER+
PR+
G1
2.9
T2
1124
1124
tamoxifen
GSM232253
GUYT2
LumB
IBD
WID
ICR2
400003049
GUYT2_50374
DistantMetastasisFree
7.92
DiseaseFree
DistantMetastasisFree
80
LN+
ER+
PR+
G2
3.8
T2
2892
2892
tamoxifen
GSM232254
GUYT2
LumB
IBD
PID
ICR1
400003050
GUYT2_50377
DistantMetastasisFree
7.3
DiseaseFree
DistantMetastasisFree
74
LN-
ER+
PR+
G1
2.5
T2
2664
2664
tamoxifen
GSM232255
GUYT2
LumA
IBD
PID
ICR2
400003051
GUYT2_50378
DistantMetastasisFree
6.08
DiseaseFree
DistantMetastasisFree
76
LN+
ER+
PR+
G1
1.69
T1c
2221
2221
tamoxifen
GSM232256
GUYT2
LumA
IBD
PID
ICR1
400003052
GUYT2_50380
DistantMetastasisFree
7
DiseaseFree
DistantMetastasisFree
55
LN+
ER+
PR+
G1
1.8
T1c
2556
2556
tamoxifen
GSM232257
GUYT2
LumA
IBD
PID
ICR2
400003053
GUYT2_50382
DistantMetastasisFree
8.08
DiseaseFree
DistantMetastasisFree
51
LN+
ER+
PR+
NA
2.3
T2
2949
2949
tamoxifen
GSM232258
GUYT2
LumB
IBE
FID
ICR3
400003054
GUYT2_50383
DistantMetastasisFree
7.08
DiseaseFree
DistantMetastasisFree
70
LN+
ER+
PR+
G2
1.8
T1c
2584
2584
tamoxifen
GSM232259
GUYT2
Her2
IBE
FID
ICR4
400003055
GUYT2_50384
DistantMetastasisFree
2.84
DiseaseFree
DistantMetastasisFree
59
LN-
ER+
PR-
NA
1.1
T1c
1038
1038
tamoxifen
GSM232260
GUYT2
Basal
IBE
FID
ICR4
400003056
GUYT2_50385
DistantMetastasis
2.41
Recurred/Progressed
DistantMetastasis
73
LN+
ER+
PR+
G3
1.5
T1c
881
881
tamoxifen
GSM232261
GUYT2
LumA
IBD
PID
ICR1
400003057
GUYT2_50389
DistantMetastasisFree
7.5
DiseaseFree
DistantMetastasisFree
71
LN+
ER+
PR+
G2
2.1
T2
2738
2738
tamoxifen
GSM232262
GUYT2
LumB
IBD
FID
ICR2
400003058
GUYT2_50391
DistantMetastasisFree
6.36
DiseaseFree
DistantMetastasisFree
67
LN-
ER+
PR+
NA
2.55
T2
2321
2321
tamoxifen
GSM232263
GUYT2
Her2
IBE
PID
ICR3
400003059
GUYT2_50395
DistantMetastasis
2.9
Recurred/Progressed
DistantMetastasis
58
LN-
ER+
PR-
G3
2.7
T2
1059
1059
tamoxifen
GSM232264
GUYT2
LumB
IBE
WID
ICR2
400003060
GUYT2_50398
DistantMetastasisFree
8.34
DiseaseFree
DistantMetastasisFree
72
LN+
ER+
PR+
G3
3.1
T2
3043
3043
tamoxifen
GSM232265
GUYT2
Basal
IBE
PID
ICR1
400003061
GUYT2_50400
DistantMetastasis
5
Recurred/Progressed
DistantMetastasis
55
LN+
ER+
PR+
G2
4.5
T2
1825
1825
tamoxifen
GSM232266
GUYT2
LumB
IBE
PID
ICR2
400003062
GUYT2_50401
DistantMetastasisFree
5.95
DiseaseFree
DistantMetastasisFree
52
LN-
ER+
PR+
G2
1.8
T1c
2170
2170
tamoxifen
GSM232267
GUYT2
Her2
IBD
FID
ICR3
400003063
GUYT2_50402
DistantMetastasis
5.28
Recurred/Progressed
DistantMetastasis
64
LN+
ER+
PR+
G2
2.5
T2
1629
1929
tamoxifen
GSM232268
GUYT2
Basal
IBE
WID
ICR3
400003064
GUYT2_50403
DistantMetastasisFree
6.36
DiseaseFree
DistantMetastasisFree
68
LN+
ER+
PR+
NA
1.85
T1c
2322
2322
tamoxifen
GSM232269
GUYT2
Basal
IBE
PID
ICR1
400003065
GUYT2_50404
DistantMetastasisFree
6.95
DiseaseFree
DistantMetastasisFree
63
LN-
ER+
PR+
G2
2
T1c
2538
2538
tamoxifen
GSM232270
GUYT2
LumA
IBD
PID
ICR2
400003066
GUYT2_50405
DistantMetastasisFree
6.14
DiseaseFree
DistantMetastasisFree
71
LN-
ER+
PR+
G1
1.1
T1c
2240
2240
tamoxifen

Group Sets View in Gene Expression Browser

Name  
All Samples Default  View
ER Status   View
Histology Differentiation Grade   View
Immune Benefit Status   View
Immunological Constant of Rejection   View
Lymph Node Status   View
Molecular Subtype   View
Pathology T Stage   View
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Module Analysis

Group Set  
All Samples
ER Status
Histology Differentiation Grade
Immune Benefit Status
Immunological Constant of Rejection
Lymph Node Status
Molecular Subtype
Pathology T Stage
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